Noopept is a peptide nootropic, often compared to Piracetam.
It is one of the newer nootropics, and is very popular because of its ease of use, small dosage size and subtle effects. Its mechanism of action suggests possible applications for treating conditions of brain trauma or cognitive degeneration like Alzheimer’s. At this time, there are no known side effects from acute usage, and no known toxicity.
The information in this post is based on current available research, my original experiences, and anecdotes and recommendations from nootropic enthusiasts.
Noopept in a Nutshell
- Noopept is a peptide nootropic, hence the name: nootropic + peptide = noopept
- Alternate name is GVS-111
- Often compared to Piracetam, similar in effect, but is not a racetam nootropic.
- Typical Noopept dosage is WAY smaller than many other nootropics
- Noopept is SUPER inexpensive! We’re talking pennies per dose.
- Oral absorption is poor; Sublingual (under the tongue) dosing is recommended
Noopept Research and Efficacy
- Noopept was shown to have a greater magnitude of effect than Piracetam (used as reference drug) in terms of recovery from vascular brain damage and brain trauma. 1
- Similar EEG patterns to Piracetam 2
- Increases NGF and BDNF content in rats 3
The one major human study seems to show more neuroprotection benefits in healthy individuals. The drug appears to have its greatest effects on people with brain damage. There have yet to be any studies to see whether it serves for cognitive enhancement purposes.
Dosage and Use
Noopept doses are typically in the range of 10 to 30 milligrams, once per day. An optimal human dosage has not been determined by research yet. Oral, ingested absorption of this nootropic peptide is notoriously inefficient because the digestive system breaks it down. 4
Capsules are available, but based on the current research, this is not an optimal route of administration.
Oral absorption is not very effective, therefore sublingual dosing is a recommended route. Sublingual means “below tongue.”
To dose sublingually, just place your dose under your tongue. Let it sit there for up to 10 minutes.
Do not try to dose capsules sublingually, you’ll just have a gelatinous mess in your mouth.
Stacking Complementary Supplements
Like many other nootropics, Noopept is often stacked with a cholinergic supplement. Doing so can mitigate any milder side effects and enhance cognitive effects.
I first covered my experiences with the nootropic back in 2013.
In short, the following subjective experiences I had:
- Improved sense of focus
- Subtle, effortless improvements in memory and recall
- Possible improvement in mood (not controlled for)
- Sublingual dosage led to increased effects (See my experience report)
Like most nootropics, you can’t really gauge it by subjective effects to tell if it’s truly doing anything. The only way to be certain until the research comes in is to run your own tests, preferably blinded with a suitable placebo or reference for control.
Noopept Side Effects
At this time, Noopept is not known to have any serious side effects when taken at the recommended dose. You can mitigate any milder side effects associated with nootropics such as headache, brain fog or irritability by taking a choline supplement.
- See “Stacking Complementary Supplements” section, above
Vendors who sell Noopept
When you purchase from these affiliate vendors, Pill Scout earns a small commission at no extra cost to you. By using affiliate links, this helps to finance my reports and keeps ads at a minimum.
This is my favorite vendor and my first affiliate on this site, c. 2013. They offer attractive prices and quality products so I purchase nootropics and supplements here often.
- Bulk Powder — 1 gram tub for $4.79; Pouches starting @ 5 grams for $6.99
- Capsules — 30 caps @ 10 mg for $7.45; 90 caps @ 10 mg for $17.95
Nootropics Depot are a new vendor to me, and they’re often recommended by the /r/Nootropics community. Their products are some of the best in the industry and come in appealing packaging.
- Bulk Powder — 5 gram jar for $7.99; 10 gram jar for $13.99
- Capsules — 30 caps @ 30 mg for $9.99; 90 caps @ 30 mg for $24.99
We earn no commission from these vendors. They’re recommended because they offer unique or quality products.
This company is an offshoot of Nootropics Depot. They offer liquid sublingual solutions for certain supplements and harder-to-find experimental substances.
- Liquid Sublingual Solution – 60 x 10mg doses in 30 ml dropper bottle for $19.99
References [ + ]
|1.||↑||(2009) Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. [PubMed Link]|
|4.||↑||Bioaccessibility of the new dipeptide nootropic drug noopept. [ResearchGate Link] – h/t MisterYouAreSoDumb|